In comparative head-to-head trials, Tirzepatide surpassed Semaglutide’s HbA1c reduction by an additional 24%. According to data from Phase III trial results in type 2 diabetic patients, Tirzepatide was non-inferior and was superior to Semaglutide with respect to the mean change in HbA1c from baseline to 40 weeks.

At all doses, Tirzepatide (5mg, 10mg, 15mg) also outperformed Semaglutide (1mg) in body weight reduction after 40-weeks. At 5mg, up to 80% of users achieved at least a 5% (15lb) reduction in body weight; at 10mg, 45% reached a 10% (20lb) reduction; and at 15mg, up to 36% of users achieved at least a 15% (25lb) reduction in body weight compared to Semaglutide users’ 54%, 24%, and 8%, respectively.

Weight loss from baseline to after 40 treatment weeks revealed that Tirzepatide (5mg, 10mg, 15mg) offered at least 30%, 60%, and up to 95% greater weight loss, respectively vs. Semaglutide 1mg.

As a GIP and GLP-1 receptor agonist, Tirzepatide is a 39-aminoacid modified peptide with a C20 fatty diacid moiety that enables albumin binding and prolongs the half-life.

Tirzepatide selectively binds to and activates the GIP and GLP-1 receptors, the targets for native GIP and GLP-1.

At therapeutic doses, it acts on the brain and suppresses appetite. Used in conjunction with a healthy diet and exercise, Tirzepatide helps patients adhere to a reduced-calorie diet, enhancing the weight loss process.

Your provider will walk you through the side effects patients report most often. The most common side effects include nausea, diarrhea, vomiting, constipation, stomach pain, headache, fatigue, dizziness, bloating, gas, and heartburn.

More serious side effects may include:

• • • Pancreatitis (inflammation of the pancreas)

    • Gallbladder problems

    • Kidney problems/failure

    • Serious allergic reactions

    • Increased heart rate

    • Depression

Read more about serious warnings and safety info.

Tirzepatide is a novel medication currently under investigation for the treatment of type 2 diabetes mellitus. It belongs to the class of drugs known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Tirzepatide works by mimicking the actions of the GLP-1 hormone, which helps regulate glucose metabolism in the body.

Clinical trials have shown promising results for tirzepatide in terms of its ability to lower blood glucose levels and improve cardiovascular outcomes when compared to other existing medications for diabetes management. Additionally, tirzepatide has demonstrated potential for weight loss in individuals with type 2 diabetes.

The weight loss observed with tirzepatide is believed to be due to its dual action as a GLP-1 receptor agonist and a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. These actions can lead to decreased appetite, increased feelings of fullness, delayed gastric emptying, and improved metabolic regulation, which contribute to weight loss.

Tirzepatide works by activating the glucagon-like peptide-1 (GLP-1) receptors in the body. GLP-1 is a hormone that is naturally produced in the intestine in response to food intake. It plays a crucial role in regulating glucose metabolism.

As a GLP-1 receptor agonist, tirzepatide mimics the actions of GLP-1 in the body. When tirzepatide is administered, it binds to and activates the GLP-1 receptors. This activation triggers a series of physiological responses that help manage blood sugar levels and promote weight loss.

Firstly, tirzepatide enhances insulin secretion from the pancreas. Insulin is a hormone that helps lower blood glucose levels by allowing glucose to enter cells and be used for energy. By increasing insulin secretion, tirzepatide helps to reduce high blood sugar levels.

Secondly, tirzepatide reduces the release of glucagon, another hormone produced by the pancreas. Glucagon raises blood glucose levels by stimulating the liver to release stored glucose into the bloodstream. By suppressing glucagon release, tirzepatide helps prevent excess glucose production and promotes glucose control.

Furthermore, tirzepatide slows down the emptying of the stomach, which leads to a prolonged feeling of fullness. This effect can help reduce calorie intake and contribute to weight loss.

Lastly, tirzepatide may have an impact on the central nervous system, specifically the brain's appetite-regulating centers. By modulating these centers, tirzepatide can help decrease appetite and food intake.

Overall, the activation of GLP-1 receptors by tirzepatide improves insulin secretion, reduces glucagon release, slows gastric emptying, and promotes a feeling of fullness, ultimately leading to improved blood sugar control and potential weight loss in individuals with type 2 diabetes.

Tirzepatide is not FDA-approved for weight loss. Moderene Body - affiliated healthcare professionals have the discretion to prescribe a medication off-label if they believe it is an appropriate course of treatment for a particular patient.

Tirzepatide may be prescribed for weight loss because it has demonstrated significant weight reduction effects in clinical trials. While its primary indication is for the treatment of type 2 diabetes, its weight loss benefits make it an attractive option for individuals who are overweight or have obesity.

The weight loss observed with tirzepatide is believed to be due to its dual action as a GLP-1 receptor agonist and a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. Activation of the GLP-1 receptors leads to decreased appetite, increased feelings of fullness, and delayed gastric emptying. These effects contribute to a reduced calorie intake and an overall decrease in food consumption.

Additionally, tirzepatide's impact on the central nervous system, specifically the brain's appetite-regulating centers, may further help suppress appetite and promote weight loss.

The weight loss effects of tirzepatide can be particularly beneficial for individuals with type 2 diabetes who also struggle with overweight or obesity, as excess weight can exacerbate insulin resistance and other metabolic issues associated with the condition. By promoting weight loss in addition to improving blood sugar control, tirzepatide can offer a comprehensive approach to managing both diabetes and weight-related health concerns.

Tirzepatide dosing starts out low, then gradually increases over the first few months until a steady dose is reached. Moderne Body - affiliated provider will work with you to find the schedule and dosing that is right for you. One of the most common dosing schedule is:

Tirzepatide is typically administered through subcutaneous (under the skin) injections. The exact dosing and administration instructions will be provided by Moderne Body - affiliated provider or as indicated in the product's prescribing information. It's important to follow the prescribed dosage and administration instructions carefully.

Here is a general overview of the common steps involved in taking tirzepatide:

Preparation: Wash your hands with soap and water and gather all the necessary supplies, including the tirzepatide pen or syringe, alcohol swabs, and a sharps disposal container.

Select the injection site: Tirzepatide injections are usually given in the abdomen (around the belly button) or the thigh. Rotate injection sites to avoid repeated injections in the same area.

Clean the injection site: Use an alcohol swab to clean the injection site and let it dry.

Prepare the tirzepatide pen or syringe: If using a pre-filled pen, remove the cap and attach the needle. If using a syringe, draw the appropriate dose of tirzepatide into the syringe as instructed by your provider.

Inject the medication: Pinch a fold of skin at the cleaned injection site and insert the needle into the skin at a 90-degree angle (or as instructed by your provider). Inject the medication slowly and steadily.

Remove the needle: Once the medication is injected, remove the needle from the skin.

Dispose of the used needle: Place the used needle in a sharps disposal container as instructed by your healthcare provider or local regulations. Do not recap the needle.

Store or dispose of the medication: Follow the specific storage instructions provided.

The cost of Tirzepatide is included in your monitored weight loss program with Moderne Body. You will have an inital $299 cost which covers your provider evaluation and medication for one month, then a recurring $299 monthly unitl you cancel. If you are not a good candidate for our program, the $299 will be refunded upon cancellation.

There are no specific foods that need to be completely avoided while taking tirzepatide. However, it is generally recommended to follow a balanced and healthy diet as part of overall diabetes management.When managing diabetes or any weight-related concerns, it is important to focus on a nutritious diet that includes a variety of foods from different food groups. Here are some general dietary recommendations that may be helpful:

• • Carbohydrates: Choose complex carbohydrates such as whole grains, fruits, vegetables, and legumes. These foods provide fiber and have a lower impact on blood sugar levels compared to refined carbohydrates.
  • Proteins: Include lean sources of protein, such as skinless poultry, fish, beans, lentils, tofu, and low-fat dairy products. Protein helps with satiety and can assist in maintaining muscle mass.
  • Fats: Opt for healthier fats like those found in nuts, seeds, avocados, and olive oil. Limit saturated and trans fats, which are commonly found in fried and processed foods.
  • Portion control: Pay attention to portion sizes to help manage calorie intake and weight. It's important to work with a healthcare professional or registered dietitian to determine appropriate portion sizes for your individual needs.
  • Sugary foods and beverages: Limit the consumption of sugary foods and beverages, as they can significantly impact blood sugar levels. Opt for sugar-free or low-sugar alternatives when possible.
  • Hydration: Stay hydrated by drinking plenty of water throughout the day. Limit the intake of sugary drinks and alcohol.

Remember that dietary recommendations may vary for each individual, depending on factors such as personal health goals, existing medical conditions, and medication usage. It's always best to consult with a healthcare professional or a registered dietitian who can provide personalized dietary guidance based on your specific needs and goals.

When trying to lose weight, people may make some common mistakes that can hinder their progress. Here are a few examples:

• • Setting Unrealistic Goals: Setting overly ambitious or unrealistic weight loss goals can lead to disappointment and frustration. It's important to set achievable and sustainable goals that align with your individual circumstances and health needs.

  • Relying on Fad Diets: Falling for the allure of fad diets that promise quick weight loss can be counterproductive. Many of these diets are restrictive, nutritionally imbalanced, and difficult to maintain in the long term. It's better to focus on adopting a balanced and sustainable eating plan.

  • Ignoring Portion Sizes: Portion control plays a significant role in weight management. It's common to underestimate portion sizes, leading to unintentional overeating. Being mindful of portion sizes and learning to listen to your body's hunger and fullness cues can be beneficial.

  • Neglecting Physical Activity: Relying solely on dietary changes without incorporating regular physical activity can impede weight loss progress. Exercise helps burn calories, build muscle, and improve overall health. Finding activities you enjoy and making them a regular part of your routine is key.

  • Emotional Eating: Using food as a coping mechanism for stress, boredom, or emotions is a common pitfall. Emotional eating can lead to consuming excess calories and hinder weight loss efforts. Finding alternative ways to cope with emotions, such as practicing mindfulness, engaging in hobbies, or seeking support, can be helpful.

  • Lack of Consistency: Consistency is crucial for weight loss success. Skipping meals, inconsistent exercise routines, or frequent deviations from healthy eating patterns can disrupt progress. Building sustainable habits and making gradual, lasting changes are key to long-term success.

  • Not Seeking Professional Guidance: Attempting to lose weight without professional guidance can be challenging. Consulting with a healthcare professional, registered dietitian, or weight loss specialist can provide personalized advice, support, and strategies tailored to your needs and health conditions.

Remember, everyone's weight loss journey is unique, and it's essential to find an approach that works best for you. Focus on making sustainable lifestyle changes, being patient with yourself, and seeking support when needed.

Your provider will walk you through the side effects patients report most often. The most common side effects include nausea, diarrhea, vomiting, constipation, stomach pain, headache, fatigue, dizziness, bloating, gas, and heartburn.

More serious side effects may include:

• • • Pancreatitis (inflammation of the pancreas)

    • Gallbladder problems

    • Kidney problems/failure

    • Serious allergic reactions

    • Increased heart rate

    • Depression

Read more about serious warnings and safety info.